Plants grow by absorbing nutrients from the soil using vascular that are stretched throughout plant bodies. However, when nutrients are scarce, “How do plants sense hunger and uptake nutrients ?” is still largely unknown. In this research unit, we will focus on the “Hunger signals,” which are signals that convey hunger from root to shoot, and the “Uptake signals,” which are signals that promote nutrient absorption from shoot to root, to clarify the molecular mechanism of flexible adaptation to nutrition deficiency stresses through communication between the roots and shoots. We aim to create a new academic discipline that analyzes and controls plant stress on an unprecedented cross-sectional scale, from molecules to individuals, and from individuals to environment.